Showing posts with label naloxone. Show all posts
Showing posts with label naloxone. Show all posts

Monday, November 30, 2015

LET'S GET ADEQUATE PAIN RELIEF












The war on drugs. 
It sounds good. 
Countless lives have been ruined because of them.
But, as usual, things go awry.



It's very irritating to me when I hear that in order to get a prescription at some of the chain pharmacies you have to go through some song and dance and convince the pharmacist that you actually need them. 

Oh, and I'm not talking about the patient.
I'm talking about the doctor.

It's ridiculous when the pharmacists puts your doctor through an interrogation. They want to know if they've tried every other remedy before prescribing opiates. This is absolutely unbelievable to me. When can a pharmacist override the doctor? Who went to medical school??

Why isn't more research being done to bring about pain relief than can block the addictive properties of the drug? Heroin and morphine bind to a specific immune receptor TLR4.  This receptor then becomes an amplifier for addiction. 

Why isn't naloxone being used more? Naloxone reverses the effects of the opioid and could save thousands of lives due to accidental overdose.  Naloxone alters brain chemistry to stop the production of dopamine. So, if it blocks the production of Mr. Feelgood (dopamine) doesn't it stand to reason it would block the craving for the drugs?

You can't tell me that the research isn't there.


There was one published in 2012. Opioid activation of toll-like receptor 4 contributes to drug reinforcement.


They talk about Naloxone in emergency rooms and taking it off prescription and being available to anyone to be used to prevent death from opioid overdose. If it can be used as a stand alone why can't it be used to create pain relief that won't be addictive. 

In October of 2013 the FDA drew huge praises from the addiction community by moving hydrocodone with acetominaphen to a Schedule 2 narcotic. The doctor cannot call in your refills. You must hand the prescription to the pharmacist personally. They have made it harder to get Lortab, Vicodin and other addictive painkillers. They are supposed to make painkillers harder to abuse. For example, they inject Oxycontin with a gel that makes it harder to crushed and snorted. This kind of abuse deterrent is supposed to be a public health priority. 

So what did they do?
They approved Zohydro. 

Zohydro is a long acting opioid. This drug is not intended for as-needed use. This is for patients who need long term, around the clock treatment. This drug is not messing around. You can't drink alcohol. Let's face it, you're not supposed to drink with any pain medication but alcohol with this medication can result in fatal hydrocodone plasma levels in the blood. You even have to be careful taking anything that contains alcohol. This can even mean cough syrup.

I love the insert on this drug. When addressing who should be prescribed this drug they talk about the opioid "naive."  Excuse me??? Zohydro is five to ten times more powerful than the currently available hydrocodone that's on the market. What the heck does opioid naive mean? To my mind? These pills shouldn't be available to everyone. It should be for terminal pain patients. If you're walking around, you shouldn't need Zohydro. It's that simple. The Attorney Generals of 28 states sent a letter to the F.D.A. protesting the approval of this drug. To be fair, the makers of Zohydro have contracted with a Canadian company to come up with an abuse deterrent formula but who knows how long that will take. This drug was meant for cancer patients but everyone knows it will be on the street soon enough. Pill mills will push these babies out and they can be crushed, snorted and will kill people.

So we are back to the problem.

Why can't we have pain relief that helps moderate to severe pain without the addictive properties? 

It's not out of the question.

When you look at all the commercials ....

And the outrageous side effects.........

And it still is approved........

You're telling me it's impossible to get adequate pain relief.....

Without the additictive properties......

I don't believe it.












Saturday, August 31, 2013

THE REVERSE WAR ON DRUGS






The war on drugs. 
It sounds good. 
Countless lives have been ruined because of them.
But, as usual, things go awry.



It's very irritating to me when I hear that in order to get a prescription at some of the chain pharmacies you have to go through some song and dance and convince the pharmacist that you actually need them. 

Oh, and I'm not talking about the patient.
I'm talking about the doctor.

It's ridiculous when the pharmacists puts your doctor through an interrogation. They want to know if they've tried every other remedy before prescribing opiates. This is absolutely unbelievable to me. When can a pharmacist override the doctor? Who went to medical school??

Well, it seems it's happening every day.

I understand that there are pill mills out there. It should be fairly easy to catch the ones who doctor shop and refill scrips from different doctors at different pharmacies. I will agree that they are abused, HOWEVER, why do we have to start living our lives from the position of the abuser? When is the pharmacy allowed to use CYA (cover your a**) as a legitimate tool for dispensing prescriptions given to you by a doctor? 

I will agree that people need to be conscientious and responsible. You don't leave them about when you have children in the home. You need to understand their power but that doesn't mean that the people who are responsible and need them to actually function on a daily basis need to be looked at as some kind of addict. 

Pain is debilitating. 

I also understand overdose but if it can be caught before it's irreversible why isn't naloxone being used more? Naloxone reverses the effects of the opioid and could save thousands of lives due to accidental overdose.  Addiction is a whole other animal and unless the root problem is dealt with all the naloxone in the world won't help. 

It just sounds like anyone who uses opiates is automatically labeled an addict.

That is SO wrong.

Where is the balance?

As usual, when it comes to legislation...

Common sense and balance are missing.